The Organic Acids Test (OAT): What It Reveals About Your Cellular Health

The Organic Acids Test (OAT) is a urine test that measures metabolic byproducts—small molecules produced when your body processes nutrients, generates energy, and performs essential cellular functions.

Think of it as a "check engine light" for your metabolism. While blood tests show what's circulating in your bloodstream, the OAT reveals what's actually happening inside your cells.

1. Mitochondrial Function (Energy Production)

The OAT examines markers from the Krebs cycle—the central pathway your mitochondria use to produce ATP (cellular energy). Elevated organic acids in this pathway can indicate:

• Nutrient cofactor deficiencies (B vitamins, CoQ10, magnesium)
• Mitochondrial inefficiency
• Oxidative stress affecting energy production

2. Neurotransmitter Metabolism

The test measures metabolites of dopamine, serotonin, and other neurotransmitters, providing insight into:

• Dopamine turnover (motivation, focus, reward)
• Serotonin metabolism (mood, sleep, gut function)
• Catecholamine balance (stress response)

3. Detoxification Capacity

Markers related to glutathione and phase II liver detoxification reveal how effectively your body neutralises and eliminates toxins.

4. Gut Dysbiosis

Specific organic acids are produced by yeast, fungi, and bacteria. Elevated levels can indicate:

• Candida overgrowth
• Bacterial imbalances (SIBO markers)
• Clostridia species activity

Blood tests measure what's in circulation—nutrients, hormones, waste products. But they don't reveal:

• How efficiently your cells are using those nutrients
• Whether your mitochondria are functioning optimally
• What metabolic byproducts are being produced

The OAT fills this gap by showing the downstream effects of cellular metabolism.

The Organic Acids Test is particularly valuable for:

• Persistent fatigue that hasn't responded to standard treatment
• Brain fog or cognitive concerns
• Mood imbalances
• Chronic gut issues
• Athletes seeking to optimise performance
• Anyone wanting a comprehensive view of their cellular health

The Organic Acids Test is included in our Metabolic Deep Dive service. It requires a 4-week lead time due to laboratory processing and involves a simple first-morning urine collection at home.